The global ADC contract manufacturing market consists of services and capabilities required for antibody-drug conjugate manufacturing such as cell line development, process and analytical development, cGMP manufacturing, and fill/finish services. ADC contract manufacturing provides end-to-end services to biopharmaceutical companies and research institutions for clinical and commercial production of antibody-drug conjugates. ADCs utilize the targeting ability of monoclonal antibodies and are comprised of monoclonal antibodies attached to cytotoxic small molecule drugs. The development of ADCs addresses unmet needs in the treatment of cancer. The increasing development of antibody therapies and ADCs specifically are driving demand for specialized outsourcing partner capabilities.
The Global ADC Contract Manufacturing Market is estimated to be valued at US$ 1.79 Bn in 2024 and is expected to exhibit a CAGR of 13. % over the forecast period 2024-2031.
Key Takeaways
Key players operating in the global ADC contract manufacturing are AbbVie Contract Manufacturing, Abzena, CARBOGEN AMCIS, Catalent Pharma Solutions, Cerbios-Pharma.
Key opportunities in the market include developing capabilities for unique linker technologies and payloads as well as additional services such as bioconjugation and fill/finish. As the oligonucleotide therapeutic market grows to include more ADCs, specialized contract manufacturers will gain opportunities in developing capabilities required for novel ADCs.
Global expansion of key players is expected over the forecast period through partnerships and acquisitions to meet the growing demand. Regional expansion into Asia Pacific and Europe will allow contract manufacturers to provide localized services and realize cost reduction for biopharmaceutical clients.
Market Drivers
One of the key drivers for the ADC contract manufacturing market is the increasing monoclonal antibody drug development. Due to the selective delivery of cytotoxic agents to cancer cells, ADCs have demonstrated clinical benefits with improved safety profiles over conventional chemotherapy. This is expected to drive continued interest and development of ADCs.
Market Restraints
High manufacturing costs of ADCs pose a restraint to the market. ADCs require specialized capabilities with significant capital requirements. ADCs also face challenges related to reproducibility, stability, and manufacturability that contract manufacturers must solve through process and analytical development services.
Segment Analysis
The global ADC contract manufacturing market is dominated by the antibody production segment. This segment is dominating as producing monoclonal antibodies is the first step in developing antibody-drug conjugates. Antibody production accounts for nearly 30-40% of the total contract manufacturing cost for ADC development. It requires specialized expertise and infrastructure for clonal selection, cell line development, and large scale manufacturing of different antibody isotypes and subclasses required for targeted drug delivery.
The downstream process development segment is the fastest growing segment. This segment includes analytical development, process characterization studies, purification method development and validation, and particle engineering. As ADC biologics move further in clinical trials and commercialization, there is growing need for customized purification strategies suited for large scale cGMP manufacturing. Additionally, enhancing drug-antibody ratio and reducing aggregates and impurities through particle engineering techniques will be key focus areas driving growth of this segment.
Regional Analysis
North America is the largest and fastest growing regional market for ADC contract manufacturing. This region accounts for over 40% market share attributed to presence of majority of blockbuster ADC drugs and large number of biopharma companies outsourcing manufacturing needs. Additionally, North America is an innovation hub for developing novel linker-payload technologies and conjugation methods. Growing ADC pipeline and increasing commercial demand for drugs like Kadcyla, Adcentris and Besponsa is further propelling regional market growth. Asia Pacific is emerging as a promising outsourcing destination, driven by expanding biologics manufacturing capacities in China, India and Singapore and growing R&D investments of global players in these regions.
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Author Bio:
Money Singh is a seasoned content writer with over four years of experience in the market research sector. Her expertise spans various industries, including food and beverages, biotechnology, chemical and materials, defense and aerospace, consumer goods, etc. (https://www.linkedin.com/in/money-singh-590844163 )
What Are The Key Data Covered In This Global ADC Contract Manufacturing Market Report?
:- Market CAGR throughout the predicted period
:- Comprehensive information on the aspects that will drive the Global ADC Contract Manufacturing Market's growth between 2024 and 2031.
:- Accurate calculation of the size of the Global ADC Contract Manufacturing Market and its contribution to the market, with emphasis on the parent market
:- Realistic forecasts of future trends and changes in consumer behaviour
:- Global ADC Contract Manufacturing Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa
:- A complete examination of the market's competitive landscape, as well as extensive information on vendors
:- Detailed examination of the factors that will impede the expansion of Global ADC Contract Manufacturing Market vendors
FAQ’s
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Q.2 Which companies are the major sources in this industry?
Q.3 What are the market’s opportunities, risks, and general structure?
Q.4 Which of the top Global ADC Contract Manufacturing Market companies compare in terms of sales, revenue, and prices?
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*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it